NCIt definition : The investigation of the impact of individual gene variations on drug responses.;
Alternative definition : NCI-GLOSS: The study of how a person's genes affect the way he or she responds to
drugs. Pharmacogenetics is being used to learn ahead of time what the best drug or
the best dose of a drug will be for a person.; CDISC-GLOSS: Study of the way drugs interact with genetic makeup or the study of genetic
response to a drug.;
NCIt note : The term is applicable to activities such as drug discovery, drug development, and
clinical practice. Drug response includes drug disposition (pharmacokinetics, PK)
and drug effect (pharmacodynamics, PD). The term drug should be considered synonymous
with investigational (medicinal) product, medicinal product and pharmaceutical (including
vaccines and other biological products).The definition of does not include other disciplines
such as proteomics and metabonomics.;