Gastrin Immunotoxin

Preferred Label : Gastrin Immunotoxin;

NCIt synonyms : G17DT; Neutralize Hormone G17; Anti-Gastrin Therapeutic Vaccine; Anti-gastrin 17; Neutralizing G17 Hormone;

NCIt related terms : G17DT IMMUNOGEN;

NCIt definition : An immunotoxin containing an epitope of human gastrin conjugated to diphtheria toxin, with antineoplastic activity. The gastrin epitope in this vaccine is chemically identical or similar to the endogenous gastrin-17 (G-17), a 17-amino acid peptide hormone that stimulates secretion of gastric acid by the stomach. Diphtheria toxin inhibits protein synthesis via modifying translation elongation factor 2 (EF-2). Vaccination with this immunotoxin may elicit production of antibodies against gastrinoma cells overexpressing gastrin, in addition to the toxic effects on protein synthesis exerted by the diphtheria toxin moiety.;

UNII : J9W34L3K8B;

Drug name : Gastrimmune;

Details

Origin ID

C1692;

UMLS CUI

C0935889;

Automatic exact mappings (from CISMeF team)
- gastrin immunogen [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- gastrin-17-diphtheria toxoid conjugate [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Fluorouracil/G17DT [NCIt concept]

Keyword's position in hierarchy(ies) :

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