Preferred Label : Trabectedin;
NCIt synonyms : Ecteinascidin; Spiro(6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo(7,8)isoquino(3,2,-b)(3)benzazocine-20,1'(2'H)-isoquinolin)-19-one,
3',4',6,6a,7,13,14,16-Octahydro-5-(acetyloxy)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-,
(6R-(6-alpha,6a-beta,7-beta,13-beta,14-beta,16-alpha,20R*))-;
NCIt related terms : Ecteinascidin 743; ET-743;
NCIt definition : A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia
turbinata with potential antineoplastic activity. Binding to the minor groove of DNA,
trabectedin interferes with the transcription-coupled nucleotide excision repair machinery
to induce lethal DNA strand breaks and blocks the cell cycle in the G2 phase.;
Alternative definition : NCI-GLOSS: A substance that comes from a type of sea squirt and is being studied in
the treatment of cancer. It binds to DNA and causes breaks in the DNA. It also blocks
the ability of the cell to repair the DNA damage, and may cause cancer cells to die.
Trabectedin is also made in the laboratory. It is a type of DNA excision repair inhibitor.;
UNII : ID0YZQ2TCP;
InChIKey : PKVRCIRHQMSYJX-AIFWHQITSA-N;
CAS number : 114899-77-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 114899-77-3
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G-SRS /a ;
Drug name : Yondelis;
Chemical formula : C39H43N3O11S;
NSC code : 648766;
Codes from synonyms : NSC0648766; CDR0000045516; CDR0000543514; CDR0000543513; 507;
Origin ID : C1691;
UMLS CUI : C1311070;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
