Preferred Label : Nanoparticle-based Manganese-containing Contrast Agent SN132D;
NCIt synonyms : MRI Contrast Agent SN132D; Nanoparticle-based Contrast Agent with Manganese SN132D; Manganese-containing Nanoparticle Contrast Agent SN132D; Manganese-based Macromolecular Contrast Agent SN132D;
NCIt definition : A contrast agent formulation composed of a polymeric core containing the paramagnetic
contrast agent manganese chloride tetrahydrate (MnCl2 4H2O), in which the Mn2 ions
are chelated to phosphonate groups, and covered with a coating layer of covalently
attached polyetyleneglycol (PEG)-polymers, that can potentially be used as a contrast
enhancer during magnetic resonance imaging (MRI). Upon intravenous administration
of the nanoparticle-based manganese-containing contrast agent SN132D, the nanoparticles
enhance absorption of the poorly absorbable contrast agent manganese, and selectively
accumulates in the tumor microenvironment (TME). Due to the retention of manganese
in the TME and its paramagnetic properties, this contrast agent enhances the visualization
and detection of tumor cells during MRI.;
Drug name : SpagoPix;
Molecule name : SN132D;
NCI Metathesaurus CUI : CL1378859;
Origin ID : C169048;
UMLS CUI : C5239340;
Semantic type(s)
- concept_is_in_subset
