Plitidepsin - CISMeF

Preferred Label : Plitidepsin;

NCIt synonyms : N-[1-(1,2-Dioxopropyl)-L-prolyl]didemnin A; Dehydrodidemnin B; DDB; Dehydrodemnin B; APLD;

NCIt related terms : aplidine;

NCIt definition : A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It is obtained from a marine organism.;

UNII : Y76ID234HW;

InChIKey : UUSZLLQJYRSZIS-LXNNNBEUSA-N;

CAS number : 137219-37-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 137219-37-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Aplidin;

NSC code : 638719;

Codes from synonyms : 50576; CDR0000046693;

Details

Origin ID

C1689;

UMLS CUI

C0388638;

Automatic exact mappings (from CISMeF team)
- Plitidepsin [ICD-11 Extension code]
- bronchiectasis [MeSH Descriptor]
Currated CISMeF NLP mapping
- plitidepsin [MeSH concept]
- plitidepsin [MeSH Supplementary Concept]
False automatic mappings
- Automated percutaneous lumbar discectomy (procedure) [SNOMED CT concept]
- DDB [MeSH concept]
- DDB [MeSH Supplementary Concept]
- Lipodystrophy, partial, acquired, susceptibility to [OMIM Phenotype]
See also inter- (CISMeF)
- aplidin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- plitidepsin [ATC Code]
- plitidepsin [MeSH concept]
- plitidepsin [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- plitidepsin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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