Preferred Label : Enadenotucirev-expressing FAP/CD3 Bispecific FAP-TAc NG-641;
NCIt synonyms : Oncolytic Adenoviral Vector-expressing FAP/CD3 Bispecific FAP-TAc NG-641; Oncolytic Adenoviral Vector Expressing FAP/CD3 Bispecific Molecule NG-641;
NCIt related terms : NG-641;
NCIt definition : An oncolytic adenoviral vector, a transgene-modified variant of enadenotucirev (EnAd),
that expresses a bi-specific T-cell activator molecule FAP-TAc together with immune
enhancer molecules C-X-C motif chemokine 9 (CXCL9), C-X-C motif chemokine 10 (CXCL10)
and interferon alpha (IFNalpha), with potential immunomodulating and antineoplastic
activities. Upon administration of NG-641, EnAd specifically infects and replicates
in tumor cells and not in normal, noncancerous tissue, and selectively expresses FAP-TAc.
The locally expressed FAP-TAc targets and binds to both fibroblast activating protein
(FAP) on cancer associated fibroblasts (CAFs) and CD3 on T-cells. This leads to T-cell
activation and T-cell mediated killing of CAFs in tumor stroma. NG-641 also encodes
the transgenes CXCL9, CXCL10 and IFNalpha. The production of CXCL9, CXCL10 and IFNalpha
leads to the recruitment and further activation of T-cells, enhancing the overall
immune response and cancer cell killing. FAP, a cell surface glycoprotein, is overexpressed
on tumor-associated fibroblasts but minimally expressed on normal, healthy cells.;
UNII : L93WSG9AAU;
Molecule name : NG 641; NG-641;
NCI Metathesaurus CUI : CL1378696;
Origin ID : C168790;
UMLS CUI : C5239121;
Semantic type(s)
- concept_is_in_subset
- has_target
