Preferred Label : Caffeine-based Cream;
NCIt synonyms : Caffeine Based Cream; Caffeine-Lipoderm Cream; Caffeine-containing Lipoderm Cream;
NCIt definition : A topical cream containing the alkaloid caffeine in a lipoderm base, with potential
anti-inflammatory, anti-fibrotic, protective and antioxidant activities. Upon topical
application of the caffeine-based cream to the affected area(s), the caffeine inhibits
phosphodiesterase (PDE) activity, thereby stimulating the degradation of fats during
lipolysis. Caffeine also reduces the levels of certain pro-inflammatory cytokines,
such as the profibrotic cytokine transforming growth factor beta (TGFb,) and matrix
metalloproteinases (MMPs), thereby preventing inflammation and protecting against
collagen degradation. In addition, caffeine protects cells from oxidative stress.
This may help protect skin, reduce skin-related complications and improve skin appearance.;
NCI Metathesaurus CUI : CL1378683;
Origin ID : C168776;
UMLS CUI : C5239110;
Semantic type(s)
concept_is_in_subset