Preferred Label : Anti-CD228/MMAE Antibody-drug Conjugate SGN-CD228A;
NCIt synonyms : Anti-CD228 Antibody-drug Conjugate SGN-CD228A; Anti-CD228/MMAE ADC SGN-CD228A; Anti-CD228-MMAE ADC SGN-CD228A; Anti-melanotransferrin ADC SGN-CD228A;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized antibody targeting the cell
surface antigen cluster of differentiation (CD228; melanotransferrin; MFI2; MELTF)
that is conjugated, via a beta-glucuronidase-cleavable linker, to the microtubule-disrupting
cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity.
Following administration, the antibody moiety of anti-CD228/MMAE ADC SGN-CD228A targets
and binds to CD228 on the surface of tumor cells. Following internalization of SGN-CD228A
and release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization.
This results in G2/M phase cell cycle arrest and apoptosis in CD228-expressing tumor
cells. CD228, a cell-surfaced, glycosylphosphatidylinoitol (GPI)-anchored glycoprotein,
belongs to the transferrin family of iron-binding proteins.;
Molecule name : SGN CD228A; SGN-CD228A;
NCI Metathesaurus CUI : CL1378671;
Origin ID : C168772;
UMLS CUI : C5239106;
Semantic type(s)
- concept_is_in_subset
- has_target
