Preferred Label : Anhydrous Enol-oxaloacetate;
NCIt synonyms : AEO;
NCIt related terms : OXALOACETIC ACID;
NCIt definition : The anhydrous form of enol-oxaloacetate, a small molecule blood glutamate scavenger,
that can be used to lower glutamate plasma levels, and has potential neuroprotective
activity. Upon administration, enol-oxaloacetate targets and binds to glutamate in
the bloodstream. This lowers glutamate plasma levels and lowers the free glutamate
available to be picked up by cells, such as tumor brain cells, thereby preventing
glutamate metabolism and glutamate-mediated signaling. This prevents the proliferation
of rapidly growing cells, such as brain tumor cells. And by lowering glutamate plasma
levels, a molecular imbalance is formed and glutamate is excreted across the blood-brain
barrier, resulting in lower free brain glutamate. This may help protect the brain
from excitotoxicity in conditions where there is a surge of glutamate production,
such as traumatic brain injury, thereby protecting neuronal cells. Glutamate, a non-essential
amino acid and the major excitatory neurotransmitter in the central nervous system
(CNS), provides energy and generates building blocks for the production of macromolecules,
which are needed for cellular growth and survival.;
UNII : 2F399MM81J;
CAS number : 328-42-7;
NCI Metathesaurus CUI : CL1378618;
Origin ID : C168687;
UMLS CUI : C5239047;
Semantic type(s)
- concept_is_in_subset
