Preferred Label : N-oleyl-phosphatidylethanolamine/Epigallocatechin Gallate Supplement;
NCIt synonyms : N-oleoyl-PE/EGCG; NOPE-EGCG; OEA-PE/EGCG; NOPE/EGCG; N-oleyl-phosphatidylethanolamine/Epigallocatechin Gallate; NOPE Plus EGCG; Oleoyl Ethanolamine-Phosphatidylethanolamine Plus EGCG;
NCIt definition : A dietary supplement composed of a phosphobioflavonic complex containing two naturally
occurring dietary ingredients: the phospholipid N-oleyl-phosphatidylethanolamine (NOPE),
which consists of the fatty acid amide oleoyl ethanolamine (OEA) bound to phosphatidylethanolamine
(PE), and the flavonol epigallocatechin gallate (EGCG), which is derived from standardized
green tea extract, with potential anorexic activity. Upon oral administration of the
NOPE/EGCG supplement, NOPE is hydrolyzed into the N-acylethanolamine N-oleyl-ethanolamide
(NOE) and phosphatidic acid. NOE inhibits anandamide, thereby preventing the increase
in appetite and promotes the activation of several intestinal receptors, which signal
the brain center to reduce food intake. EGCG inhibits enzymes that contribute to the
degradation of catecholamines, stimulates lipolysis, and promotes weight loss. NOPE
and EGCG may work together to provide satiety, improve adherence to a diet, improve
performance on impulsivity, and shift fat and sweet preference. This may reduce weight
gain and may increase weight loss.;
NCIt note : NCT01976156;
Drug name : PhosphoLean;
NCI Metathesaurus CUI : CL1378713;
Origin ID : C168614;
UMLS CUI : C5238984;
Semantic type(s)
- Food [UMLS semantic type]
concept_is_in_subset