Preferred Label : Thymidylate Synthase Inhibitor CX1106;
NCIt synonyms : TSI CX1106; TS Inhibitor CX1106;
NCIt definition : A thymidylate synthase (TS) inhibitor with potential antineoplastic activity. Upon
administration, TS inhibitor CX1106 binds to and inhibits TS. This reduces thymine
nucleotide synthesis, inhibits DNA synthesis and cell division, causes DNA damage
and leads to tumor cell apoptosis. TS catalyzes the conversion of deoxyuridine monophosphate
(dUMP) to deoxythymidine monophosphate (dTMP), an essential precursor for DNA synthesis,
and plays a key role in cell growth and division.;
Molecule name : CX-1106; CX 1106;
NCI Metathesaurus CUI : CL972813;
Origin ID : C168609;
UMLS CUI : C5238981;
Semantic type(s)
- concept_is_in_subset
