Preferred Label : Kanitinib;
NCIt definition : A tyrosine kinase inhibitor targeting the oncoprotein c-Met (hepatocyte growth factor
receptor; HGFR; MET) and vascular endothelial growth factor receptor 2 (VEGFR2), with
potential anti-angiogenic and antineoplastic activities. Upon oral administration,
kanitinib targets and binds to c-Met and VEGFR2, thereby disrupting c-Met- and VEGFR2-dependent
signal transduction pathways. This may induce cell death in tumor cells overexpressing
c-Met and/or VEGFR2 protein. c-Met and VEGFR2 are both overexpressed in many tumor
cell types and play key roles in tumor cell proliferation, survival, invasion, metastasis,
and tumor angiogenesis.;
Molecule name : CX-1003; CX 1003;
NCI Metathesaurus CUI : CL972814;
Origin ID : C168608;
UMLS CUI : C5238980;
Semantic type(s)
- concept_is_in_subset
