Preferred Label : CD28/ICOS Antagonist ALPN-101;
Obsolete resource : true;
NCIt synonyms : ICOSL vIgD-Fc;
NCIt definition : An Fc fusion protein comprised of a human inducible T-cell costimulator ligand (ICOSL)
variant immunoglobulin domain (vIgD) that binds to both inducible T-cell costimulator
(ICOS; CD278) and cluster of differentiation 28 (CD28), with potential immunomodulating
activity. Upon administration, CD28/ICOS antagonist ALPN-101 targets and binds to
both CD28 and ICOS expressed on certain T-cells. This prevents the activation of CD28
and ICOS by its ligands, thereby blocking the two T-cell costimulatory pathways and
the resulting T-cell activation. CD28 is involved in initiation of the pathogenic
process in graft versus host disease (GVHD). Following initial activation, CD28 is
often downregulated while ICOS is upregulated, possibly sustaining GVHD. Dual blockade
of CD28 and ICOS may be superior to individual blockade of CD28 or ICOS alone.;
NCIt note : See 'Acazicolcept(C179069)';
Concept status : Retired_Concept;
Molecule name : ALPN 101; ALPN-101;
NCI Metathesaurus CUI : CL972908;
Origin ID : C168584;
UMLS CUI : C5238967;
Semantic type(s)
- UMLS correspondences (same concept)
