NCIt definition : A humanized immunoglobulin G1 (IgG1) bispecific antibody directed against both the
tumor-associated antigen (TAA) six transmembrane epithelial antigen of the prostate
1 (STEAP1) and the T-cell surface antigen CD3, with potential immunostimulating and
antineoplastic activities. Upon administration, xaluritamig targets and binds to both
STEAP1 expressed on the surface of tumor cells and CD3 expressed on T-cells. This
results in the cross-linking of tumor cells and T-cells, and induces a cytotoxic T-lymphocyte
(CTL) response against STEAP1-expressing tumor cells. STEAP1 is overexpressed in a
variety of cancers including prostate cancer.;
Semantic type(s)