Preferred Label : Manganese/L-alanine/Vitamin D3-containing Contrast Agent Formulation;
NCIt synonyms : Manganese-based Contrast Agent CMC 001;
NCIt definition : An orally bioavailable contrast agent formulation composed of the contrast agent manganese
chloride tetrahydrate (MnCl2 4H2O), and the absorption promoters L-alanine and vitamin
D3, that can potentially be used as a contrast enhancer during hepatobiliary magnetic
resonance imaging (MRI). Upon oral administration of the manganese/L-alanine/vitamin
D3-containing contrast agent formulation, L-alanine and vitamin D3 enhance the absorption
of the poorly absorbable contrast agent manganese, mainly from the small intestines.
Upon absorption, the trace element manganese is taken up by normal, healthy hepatocytes.
Due to the retention of manganese in the hepatocytes and its paramagnetic properties,
this contrast agent enhances the visualization of normal liver tissue during an MRI.
As tumor cells do not accumulate manganese, abnormal hepatic cells, such as hepatic
tumor cells, will become clearly detectable against the enhanced normal liver tissue
on the MR image. This enhances the visualization and detection of liver lesions, including
liver metastases.;
Drug name : Mangoral;
Molecule name : CMC-001; CMC 001;
NCI Metathesaurus CUI : CL972855;
Origin ID : C168527;
UMLS CUI : C5238917;
Semantic type(s)
- concept_is_in_subset
