Preferred Label : Exatecan Mesylate;
NCIt synonyms : Exatecan Mesylate Hydrate; Exatecan Mesylate Dihydrate; 10H,13H-Benzo(de)pyrano(3'm4':6,7)indolizino(1,2-b)quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-,
(1S-trans)-, Methanesulfonate (1:1) (Salt), Dihydrate;
NCIt related terms : DX-8951f;
NCIt definition : A semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity.
Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex
between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting
DNA replication and triggering apoptotic cell death. This agent does not require enzymatic
activation and exhibits greater potency than camptothecin and other camptothecin analogues.
(NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that is a type of topoisomerase inhibitor.;
UNII : D2VJ1CC26Q;
InChIKey : FXQZOHBMBQTBMJ-MWPGLPCQSA-N;
CAS number : 197720-53-9;
Molecule name : DX-8951f;
Chemical formula : C24H22FN3O4.CH4O3S.2H2O;
Codes from synonyms : CDR0000046200; CDR0000043972;
Origin ID : C1679;
UMLS CUI : C0935945;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_component_of_chemotherapy_regimen
- is_salt_form_of
