Preferred Label : Recombinant Fibroblast Growth Factor 2;
NCIt synonyms : Basic Fibroblast Growth Factor; Prostatropin; Fibroblast Growth Factor 2; FGF2; HBGF-2; bFGF; Therapeutic Fibroblast Growth Factor-2;
NCIt definition : A recombinant therapeutic agent which is chemically identical to or similar to endogenous
fibroblast growth factor 2 (FGF-2). Reflecting its endogenous role, therapeutic FGF-2
exhibits a wide spectrum of biological activities, including the promotion of growth
and differentiation in target cells, the regulation of hormone secretion, and the
promotion of angiogenesis. This agent's mitogenic effects on fibroblasts and endothelial
cells indicates a potential role in therapeutic angiogenesis and wound healing. In
addition, therapeutic FGF-2 may stimulate neurogenesis and protect neurons against
degeneration; FGF-2 supplementation via gene transfer may reduce neuronal degeneration
in experimental animal models. (NCI04);
CAS number : 103107-01-3;
Origin ID : C1674;
UMLS CUI : C1522505;
Semantic type(s)
