Signet Ring Cell/Histiocytoid Carcinoma

Preferred Label : Signet Ring Cell/Histiocytoid Carcinoma;

NCIt synonyms : Signet-Ring Cell/Histiocytoid Carcinoma; Signet Ring Cell/Histiocytoid Carcinoma;

NCIt definition : A rare aggressive adnexal carcinoma that affects the eyelid and rarely the axilla. Morphologically, it is characterized by the presence of signet ring cells or histiocytoid epithelial cells with eosinophilic cytoplasm infiltrating the dermis, often in a single file pattern.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL978753;

Details

Origin ID

C167369;

UMLS CUI

C5238498;

Currated CISMeF NLP mapping
- Signet ring cell/histiocytoid carcinoma [ICD-11 Extension code]
Disease excludes abnormal cell
- Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
Disease may have findings
- Histiocytoid Differentiation [NCIt concept]
Has associated anatomic sites
- Integumentary System [NCIt concept]
- Skin [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Adenocarcinoma Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
disease_has_finding
- Adnexal Differentiation [NCIt concept]
- Aggressive Clinical Course [NCIt concept]
- Carcinomatous Component Present [NCIt concept]
- Cutaneous Involvement [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Exocrine System [NCIt concept]
- Skin [NCIt concept]
- Sweat Gland [NCIt concept]
disease_may_have_abnormal_cell
- Adenocarcinoma Cell with Eosinophilic Granular Cytoplasm [NCIt concept]
- Signet Ring Adenocarcinoma Cell [NCIt concept]
disease_may_have_molecular_abnormality
- CDH1 Gene Mutation [NCIt concept]
- CDKN1B Gene Mutation [NCIt concept]
- NTRK3 Gene Mutation [NCIt concept]
- PIK3CA Gene Mutation [NCIt concept]
- TP53 Gene Mutation [NCIt concept]

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