Preferred Label : HPV E6/E7-encoding Arenavirus Vaccine HB-201;
NCIt synonyms : HB-201 Cancer Vaccine; Arenavirus Vector-based Vaccine HB-201; Arenavirus Vector-based Vaccine-expressing HPV 16 E7E6 HB-201;
NCIt definition : A cancer vaccine consisting of a replication-attenuated arenavirus lymphocytic choriomeningitis
virus (LCMV) encoding the inactivated fusion protein of the viral oncoproteins E6
and E7 derived from the human papillomavirus (HPV) serotype 16, with potential immunomodulating
and antineoplastic activities. Upon administration, HPV E6/E7-encoding arenavirus
vaccine HB-201 induces expression of the E6/E7 proteins and stimulates the host immune
system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing
HPV16 E6 and E7, resulting in tumor cell lysis. Oncoproteins E6 and E7 play a key
role in the development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma.;
Molecule name : HB-201; HB 201;
NCI Metathesaurus CUI : CL972322;
Origin ID : C167349;
UMLS CUI : C5238481;
Semantic type(s)
- concept_is_in_subset
- has_target
