Preferred Label : Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cells;
NCIt synonyms : Allogeneic Apograft Stem Cells; FasL-treated Mobilized Peripheral Blood Cells; Apograft-treated Allogeneic MPBCs; Apograft-treated MPBCs; Fas Ligand-treated Allogeneic Mobilized Peripheral Blood Cell Product; Apograft-incubated Mobilized Peripheral Blood Stem Cells;
NCIt definition : A donor graft derived from allogeneic filgrastim (granulocyte-colony stimulating factor;
G-CSF)-mobilized peripheral blood cells (MPBC) that have been incubated with the recombinant
human Fas ligand (FasL) APO010 ex vivo, and that can potentially be used for immune
reconstitution purposes. The incubation of the hematopoietic stem cell graft with
the apoptotic mediator Fas ligand (FasL) selectively induces apoptosis of mature T-cells
which express high levels of Fas receptor, such as T stem cell memory (TSCM), T central
memory (TCM), and T effector memory (TEM) cells and the pro-inflammatory T-helper
cells (Th) Th1 and Th17 subsets while sparing CD34-positive stem and progenitor cells.
Upon washing and further ex vivo preparations, and upon allogeneic hematopoietic stem
cell transplantation (HSCT) with the FasL-treated allogeneic MPBCs, these cells provide
hematopoietic cell recovery, preserve the graft-versus-leukemia (GvL) effects, and
may prevent graft-versus-host disease (GvHD).;
NCI Metathesaurus CUI : CL972303;
Origin ID : C167326;
UMLS CUI : C5238462;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
