Preferred Label : Sardomozide;
NCIt synonyms : Amidinoindan-1-one.2'-amidinohydrazone;
NCIt related terms : CGP 48664; 2-[4-(Aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide;
NCIt definition : A methylglyoxal-bis(guanylhydrazone) (MGBG) derivative with potential antineoplastic
and antiviral properties. Sardomozide selectively binds to and inhibits S-adenosylmethionine
decarboxylase (SAMDC), an enzyme essential for the biosynthesis of polyamines, such
as spermine and spermidine that bind to DNA and play critical roles in cell division,
cell differentiation and membrane function. By inhibiting SAMDC, sardomozide reduces
the intracellular polyamine concentration, thereby interfering with cell growth and
differentiation. In addition, this agent also exhibits anti-HIV effect via suppressing
expression of eukaryotic translation initiation factor 5A (eIF-5A), which is essential
for retroviral replication.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the family of drugs called S-adenosylmethionine decarboxylase inhibitors.;
UNII : CEB05S0B9I;
InChIKey : CYPGNVSXMAUSJY-CXUHLZMHSA-N;
CAS number : 149400-88-4;
Molecule name : CGP-48664; SAM 486A;
Chemical formula : C11H14N6;
Codes from synonyms : 50511; CDR0000045522;
Origin ID : C1673;
UMLS CUI : C1527126;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
