Preferred Label : STING Agonist BMS-986301;
NCIt related terms : STING Agonist IBMS-986301;
NCIt definition : An agonist of stimulator of interferon genes (STING) protein, with potential immunoactivating
and antineoplastic activities. Upon administration, STING agonist BMS-986301 targets
and binds to STING and activates the STING pathway, which promotes IKK-related kinase
TANK-binding kinase 1 (TBK1) signaling and activates nuclear factor-kappa B (NF-kB)
and interferon regulatory factor 3 (IRF3) in immune cells in the tumor microenvironment
(TME). This leads to the production of pro-inflammatory cytokines, including interferons
(IFNs). Specifically, expression of IFN-beta (IFNb) enhances the cross-presentation
of tumor-associated antigens (TAAs) by dendritic cells (DCs) to cytotoxic T-lymphocytes
(CTLs). This results in a CTL-mediated immune response against tumor cells and causes
tumor cell lysis. STING, a transmembrane protein that activates immune cells in the
TME, plays a key role in the activation of the innate immune system.;
Molecule name : BMS-986301; BMS 986301;
NCI Metathesaurus CUI : CL972276;
Origin ID : C167292;
UMLS CUI : C5238434;
Semantic type(s)
- concept_is_in_subset
- has_target
