Preferred Label : STING-expressing E. coli SYNB1891;
NCIt synonyms : STING-expressing Escherichia coli strain SYNB1891;
NCIt definition : A non-pathogenic strain of Escherichia coli (E. coli) bacteria that has been engineered
to express stimulator of interferon genes (STING; transmembrane protein 173; TMEM173)
protein, with potential immunoactivating and antineoplastic activities. Upon intratumoral
administration, STING-expressing E. coli SYNB1891 are engulfed by antigen presenting
cells (APCs) within the tumor. STING-mediated pathways within the APCs are then activated
resulting in a type I interferon (IFN) response which promotes initiation and propagation
of tumor-specific T-cell responses. In addition, the bacterial component of SYNB1891
may further stimulate the innate immune system via Toll-like receptors (TLRs) which
may enhance the magnitude of the overall immune response. STING, a transmembrane protein
that activates immune cells in the tumor microenvironment (TME), plays a key role
in the activation of the innate immune system.;
Molecule name : SYNB 1891; SYNB-1891;
NCI Metathesaurus CUI : CL972256;
Origin ID : C167270;
UMLS CUI : C5238415;
Semantic type(s)
- concept_is_in_subset
- has_target
