NCIt definition : An orally bioavailable, selective, second-generation inhibitor of valosin-containing
protein (VCP)/p97, with potential antineoplastic activity. Upon oral administration,
p97 inhibitor CB-5339 binds to and inhibits the activity of p97. This prevents ubiquitin-dependent
protein degradation and causes cellular accumulation of poly-ubiquitinated proteins.
The inhibition of endoplasmic reticulum (ER)-associated protein degradation activates
the ER-dependent stress response pathway, and leads to both an induction of apoptosis
and the inhibition of cell proliferation in susceptible tumor cells. VCP/p97, a type
II AAA ATPase, plays a key role in cellular protein homeostasis processes including
ER-associated degradation (ERAD), chromatin associated degradation (CAD) and the DNA
damage response (DDR). Its overexpression in many tumor cell types is associated with
increased tumor cell proliferation and survival.;
Semantic type(s)