Preferred Label : Allogeneic NKG2DL-targeting CAR-grafted Gamma Delta T Cells;
NCIt synonyms : Allogeneic NKG2DL-targeting CAR-gd T-cells;
NCIt definition : A preparation of a subset of allogeneic T-lymphocytes that express only gamma chain
and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric
antigen receptor (CAR) encoding for human natural-killer group 2, member D receptor
protein (NKG2D or KLRK1; natural killer cell activating receptor group 2D), with potential
immunomodulating and antineoplastic activities. Upon administration of the NKG2DL-targeting
CAR-grafted gamma delta T cells, these cells specifically target and bind to tumor
cells expressing NKG2D ligands (NKG2DL). This induces secretion of pro-inflammatory
cytokines and results in the lysis of NKG2DL-expressing tumor cells. In addition,
these cells target, bind to and kill NKG2DL-expressing tumor-associated endothelial
cells in the neovasculature and immunosuppressive cells, such as regulatory T-cells
(Tregs) and myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment
(TME) that express NKG2D ligands. Gamma/delta T-lymphocytes play a key role in the
activation of the immune system and do not require major histocompatibility complex
(MHC)-mediated antigen presentation to exert their cytotoxic effect. Ligands for NKG2D,
such as MHC class I chain-related protein A (MICA), MICB, and members of the UL16-binding
proteins (ULBP)/retinoic acid early transcript 1 (RAET1) family, are overexpressed
on infected cells and most cancer cell types, but are not expressed on most normal,
healthy cells.;
Molecule name : CTM-N2D;
NCI Metathesaurus CUI : CL972443;
Origin ID : C167220;
UMLS CUI : C5238373;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
