Preferred Label : Partially Engineered T-regulatory Cell Donor Graft TRGFT-201;
NCIt synonyms : T-cell-Depleted Graft With Additional Infusion of Conventional T Cells and Regulatory
T Cells; Partially Engineered and Enriched Treg Donor Graft TRGFT-201;
NCIt definition : A T-regulatory (Treg) cell donor graft that has been partially engineered by depleting
all the T-cells and then enriching the graft with infusions of conventional T-cells,
Tregs and CD34 stem cells derived from peripheral blood from either related or unrelated
matched donors, with potential immunomodulating activity. Upon administration of the
partially engineered T-regulatory cell donor graft TRGFT-201 following myeloablation,
the allograft may induce tolerance in patients undergoing allogeneic hematopoietic
stem cell transplantation (AHSCT) as treatment for hematologic malignancies.;
Drug name : TregGraft; Orca-T;
Molecule name : TRGFT 201; TRGFT-201;
NCI Metathesaurus CUI : CL972434;
Origin ID : C167207;
UMLS CUI : C5238364;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
