Preferred Label : KRASG12C Inhibitor JNJ-74699157;
NCIt synonyms : G12C Mutant KRAS Protein Inhibitor JNJ-74699157;
NCIt definition : An orally available, small molecule inhibitor of the oncogenic Kirsten rat sarcoma
virus homolog KRAS glycine-to-cysteine substitution mutation, G12C, with potential
antineoplastic activity. Upon oral administration JNJ-74699157 targets and binds to
cytosine 12 within the switch II pocket of GDP-bound KRAS G12C, thereby inhibiting
mutant KRAS-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves
an important role in cell signaling, division and differentiation. Mutations of KRAS
may induce constitutive signal transduction leading to tumor cell growth, proliferation,
invasion, and metastasis.;
Molecule name : JNJ 74699157; JNJ-74699157; ARS 3248; ARS-3248;
NCI Metathesaurus CUI : CL972386;
Origin ID : C167157;
UMLS CUI : C5238316;
Semantic type(s)
- concept_is_in_subset
- has_target
