Preferred Label : Recombinant Human Monocyte Chemoattractant Protein-2;
NCIt synonyms : Human Monocyte Chemoattractant Protein-2; CCL8; MCP-2; Recombinant Human Macrophage Chemoattractant Protein-2;
NCIt definition : A recombinant agent, chemically identical or similar to the endogenous small inducible
cytokine A8 (MCP-2). This agent is a member of the Cys-Cys chemokine family, with
potent chemoattractant effect for monocytes, basophils and T lymphocytes and antiviral
activity. MCP-2 is a ligand for CC chemokine receptor 5 (CCR5) on CD4 lymphocytes,
and competitively block R5 HIV-1 cellular entry via interaction with CCR5, through
direct interference with HIV-1 gp120 binding. This agent induces a robust, pertussis
toxin-sensitive calcium flux in primary lymphocytes.;
NCIt note : Concept name is incorrect--Macrophage should be Monocyte;
Origin ID : C1671;
UMLS CUI : C1522249;
Semantic type(s)
