Acute Myeloid Leukemia with RAM Immunophenotype

Preferred Label : Acute Myeloid Leukemia with RAM Immunophenotype;

NCIt synonyms : AML with RAM Immunophenotype;

NCIt definition : A high risk pediatric acute myeloid leukemia with an extremely poor prognosis. The blasts show bright CD56 expression, dim-to-negative expression of CD45 and CD38, and lack of HLA-DR expression. This immunophenotype was named after one of the pediatric patient's initials (RAM), from Children's Oncology Group (COG) clinical trial AAML0531.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL972080;

Détails

Origin ID

C167089;

UMLS CUI

C5238255;

Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Aggressive Clinical Course [NCIt concept]
- Childhood Lesion [NCIt concept]
- HLA-DR-Negative Neoplastic Cells Present [NCIt concept]
- High Risk Acute Myeloid Leukemia [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Neoplastic Cells with Bright CD56 Expression Present [NCIt concept]
- Neoplastic Cells with CD38 Dim-to-Negative Expression Present [NCIt concept]
- Neoplastic Cells with CD45 Dim-to-Negative Expression Present [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]

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