NCIt definition : An orally bioavailable calcitonin gene-related peptide (CGRP) receptor antagonist
that can be used in the preventive treatment of migraines. Upon oral administration,
atogepant targets, binds to and blocks the activity of CGRP receptor, thereby preventing
CGRP-mediated signaling. By blocking the CGRP-mediated pathways, atogepant is able
to relieve or prevent migraine. CGRP-mediated signaling plays a key role in migraine
pathogenesis.;