Preferred Label : Nomacopan;
NCIt synonyms : Recombinant Ornithodoros moubata Complement Inhibitor; Recombinant Ornithodoros moubata Saliva-derived Small Protein Complement C5 Inhibitor; Recombinant EV576; Complement C5-inhibitor rEV576; rEV576; Recombinant OmCI;
NCIt definition : A recombinant small peptide inhibitor of the terminal complement pathway protein C5
originally derived from a protein in the saliva of the Ornithodoros moubata tick,
with potential anti-inflammatory and cytoprotective activities. Upon administration,
nomacopan targets and binds to a unique site on the terminal complement protein C5,
which blocks C5 cleavage into the pro-inflammatory components C5a and C5b, and prevents
the C5b-dependent assembly of the membrane-attack complex (MAC; C5b-9). This prevents
MAC-mediated lysis and destruction of red blood cells (RBCs) in paroxysmal nocturnal
hemoglobinuria (PNH) and prevents tissue destruction in various other complement-mediated
inflammatory and autoimmune diseases. In addition, this C5 inhibitor targets, binds
to and inhibits the activity of leukotriene B4 (LTB4), thereby further preventing
inflammatory-mediated cell destruction.;
UNII : 79V7Q9VIWQ;
CAS number : 875125-19-2;
Drug name : Coversin;
NCI Metathesaurus CUI : CL972006;
Origin ID : C167012;
UMLS CUI : C5139797;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
