" /> Miriplatin - CISMeF





Preferred Label : Miriplatin;

NCIt definition : A lipophilic platinum complex and oxaliplatin analog that contains two myristate chains, with potential antineoplastic activity. Upon administration of miraplatin, the platinum moiety forms complexes with nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links, resulting in apoptosis and cell growth inhibition. Compared to platinum alone, the lipophilic formulation allows increased delivery of platinum to the tumor site, thereby increasing efficacy while reducing systemic toxicity.;

UNII : 780F0P8N4I;

InChIKey : BGIHRZPJIYJKAZ-BLUNCNMSSA-L;

CAS number : 141977-79-9;

Drug name : Miripla;

Molecule name : SM-11355;

NCI Metathesaurus CUI : CL971999;

Codes from synonyms : 120535;

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31/05/2025


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