NCIt definition : A lipophilic platinum complex and oxaliplatin analog that contains two myristate chains,
with potential antineoplastic activity. Upon administration of miraplatin, the platinum
moiety forms complexes with nucleophilic groups such as GC-rich sites in DNA, inducing
intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links, resulting
in apoptosis and cell growth inhibition. Compared to platinum alone, the lipophilic
formulation allows increased delivery of platinum to the tumor site, thereby increasing
efficacy while reducing systemic toxicity.;