Volagidemab - CISMeF

Preferred Label : Volagidemab;

NCIt definition : A fully human immunoglobulin G2 (IgG2) monoclonal antibody targeting the human glucagon receptor (GCGR), that may be used for the treatment of hyperglycemia. Upon administration, volagidemab specifically targets and binds to GCGR, thereby blocking GCGR signaling. This may inhibit glucagon activity, thereby decreasing hepatic glycogenolysis and gluconeogenesis and ultimately lowering blood glucose levels. Glucagon, a hormone that increases blood sugar, plays an important role in the regulation of blood glucose levels.;

UNII : 77JYS6UZ0M;

CAS number : 1233956-13-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1233956-13-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : REMD 477; REMD-477; AMG-477;

NCI Metathesaurus CUI : CL971997;

Details

Origin ID

C167005;

UMLS CUI

C5227441;

Automatic exact mappings (from CISMeF team)
- volagidemab [MeSH concept]
Currated CISMeF NLP mapping
- volagidemab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- volagidemab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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