Preferred Label : Onfekafusp Alfa;
NCIt synonyms : Recombinant Human Fusion Protein L19TNFalpha; L19-TNF-alpha; Fibromun;
NCIt definition : An immunocytokine consisting of human pro-inflammatory cytokine tumor necrosis factor
alpha (TNFalpha) fused to a human single-chain variable fragment (scFv) directed against
the extra-domain B (ED-B) of fibronectin (L19), with potential immunopotentiating
and antineoplastic activities. Upon adinistration, the L19 moiety of onfekafusp alfa
binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature.
In turn, the TNFalpha moiety may locally induce an immune response against ED-B fibronectin-expressing
tumor cells and may specifically decrease the proliferation of ED-B-expressing tumor
cells. ED-B is predominantly expressed during angiogenesis and tumor growth.;
UNII : 6HXC0O6JMV;
CAS number : 1957239-88-1;
NCI Metathesaurus CUI : CL972185;
Origin ID : C166939;
UMLS CUI : C5238181;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
