Preferred Label : Onfekafusp Alfa;
NCIt synonyms : Recombinant Human Fusion Protein L19TNFalpha; L19-TNF-alpha; Fibromun;
NCIt definition : An immunocytokine consisting of human pro-inflammatory cytokine tumor necrosis factor
alpha (TNFalpha) fused to a human single-chain variable fragment (scFv) directed against
the extra-domain B (ED-B) of fibronectin (L19), with potential immunopotentiating
and antineoplastic activities. Upon adinistration, the L19 moiety of onfekafusp alfa
binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature.
In turn, the TNFalpha moiety may locally induce an immune response against ED-B fibronectin-expressing
tumor cells and may specifically decrease the proliferation of ED-B-expressing tumor
cells. ED-B is predominantly expressed during angiogenesis and tumor growth.;
UNII : 6HXC0O6JMV;
CAS number : 1957239-88-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1957239-88-1
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G-SRS /a ;
NCI Metathesaurus CUI : CL972185;
Origin ID : C166939;
UMLS CUI : C5238181;
Semantic type(s)
- concept_is_in_subset
