Preferred Label : Isunakinra;
NCIt definition : A recombinant protein resembling interleukin-1 (IL-1) receptor antagonist (IL-1Ra),
with potential anti-inflammatory, immunomodulatory and antineoplastic activities.
Upon administration, isunakinra targets and binds to the IL-1 receptor type 1 (IL-1-R1;
IL-1R1; IL1R1), thereby blocking the binding of IL-1 alpha and beta to and activation
of its receptor. Blockade of IL-1 activity and IL-1R1-mediated signaling inhibits
the release of other pro-inflammatory mediators and may suppress inflammation and
immunological responses. This may also abrogate the inflammatory and the immunosuppressive
nature of the tumor microenvironment (TME), and may inhibit tumor growth, invasion,
metastasis, and angiogenesis. IL-1/IL-1R1 signaling plays a key role in inflammation,
which is present in various disease states including certain types of cancer.;
UNII : 5QM1ZK6VXZ;
CAS number : 1357527-05-9;
NCI Metathesaurus CUI : CL971851;
Origin ID : C166859;
UMLS CUI : C4519727;
Semantic type(s)
- concept_is_in_subset
