NCIt definition : A synthetic and inhibitory triggering receptor expressed on myeloid cells-1 (TREM-1)
peptide, with potential anti-inflammatory and immunomodulatory activities. Upon administration,
nangibotide binds to TREM-1 ligand and inhibits the binding of the TREM-1 ligand to
TREM-1. This blocks the TREM-1-mediated amplification of innate immunity signaling,
and prevents the production of pro-inflammatory mediators and inflammation. TREM-1,
an immune-receptor expressed in neutrophils, mature monocytes, macrophages, natural
killer (NK) cells and endothelial cells, is up-regulated following Toll-Like Receptors
(TLR) or NOD-like receptors (NLR) signaling. It plays a key role in the amplification
of inflammatory and innate immune responses.;
UNII : 59HD7BLX9H;
CAS number : 2014384-91-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2014384-91-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;