" /> Nangibotide - CISMeF





Preferred Label : Nangibotide;

NCIt definition : A synthetic and inhibitory triggering receptor expressed on myeloid cells-1 (TREM-1) peptide, with potential anti-inflammatory and immunomodulatory activities. Upon administration, nangibotide binds to TREM-1 ligand and inhibits the binding of the TREM-1 ligand to TREM-1. This blocks the TREM-1-mediated amplification of innate immunity signaling, and prevents the production of pro-inflammatory mediators and inflammation. TREM-1, an immune-receptor expressed in neutrophils, mature monocytes, macrophages, natural killer (NK) cells and endothelial cells, is up-regulated following Toll-Like Receptors (TLR) or NOD-like receptors (NLR) signaling. It plays a key role in the amplification of inflammatory and innate immune responses.;

UNII : 59HD7BLX9H;

CAS number : 2014384-91-7;

Molecule name : LR 12; LR-12;

NCI Metathesaurus CUI : CL971828;

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31/07/2025


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