NCIt definition : A humanized immunoglobulin G4 (IgG4) monoclonal antibody targeting calcitonin-gene
related peptide (CGRP) ligand, that can be used in the preventive treatment of migraine.
Upon subcutaneous administration, galcanezumab specifically targets and binds to CGRP
ligand, and blocks the binding of the CGRP ligand to its receptor. This blocks the
CGRP pathway and prevents migraine.;