NCIt definition : The recombinant analog of endogenous beta (B) chain of the cytokine platelet-derived
growth factor (PDGF). Synthesized primarily by megakaryocytes, endogenous PDGF consists
of two related peptide chains, PDGF-A and PDGF-B. PDGF functions as a local autocrine
and paracrine growth factor in many cellular processes. Recombinant PDGF, alone and
in combination with other agents, may be useful in promoting bone formation and soft
tissue repair. (NCI04);