Preferred Label : Piclidenoson;
NCIt synonyms : beta-D-Ribofuranuronamide, 1-Deoxy-1-(6-(((3-iodophenyl)methyl)amo)-9H-purin-9-yl)-N-methyl-; Methyl 1-[N6-(3-iodobenzyl)-adenin-9-yl]-b-D-ribofuronamide; N(6)-Ibamu; IB-MECA; N(6)-(3-Iodobenzyl)-5'-N-methylcarboxamidoadenosine; 1-Deoxy-1-(6-(((3-iodophenyl)methyl)amino)-9H-purin-9-yl)-N-methyl-beta-D-ribofuranuronamide; 3-IB-Meca;
NCIt definition : An orally bioavailable, adenosine A3 receptor (A3AR) agonist with potential anti-inflammatory
activity. Upon administration, piclidenoson selectively targets, binds to and activates
the cell surface-expressed A3AR, thereby activating transduction pathways in which
A3AR plays a key role. This inhibits nuclear factor-kappa B (NF-kB) signaling and
inhibits inflammatory cytokine production, such as tumor necrosis factor (TNF) and
several interleukins. A3AR, a G protein-coupled receptor, plays a key role in many
inflammatory diseases, and in certain types of cancer.;
UNII : 30679UMI0N;
InChIKey : HUJXGQILHAUCCV-MOROJQBDSA-N;
CAS number : 152918-18-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 152918-18-8
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G-SRS /a ;
Molecule name : SI-615; CF-101;
NCI Metathesaurus CUI : CL971866;
Origin ID : C166615;
UMLS CUI : C4489756;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
