Preferred Label : Filgotinib Hydrochloride;
NCIt definition : The hydrochloride salt form of filgotinib, an orally bioavailable inhibitor of the
tyrosine kinase Janus kinase 1 (JAK1), with potential anti-inflammatory and immunomodulating
activities. Upon oral administration, filgotinib specifically targets, binds to, and
inhibits the phosphorylation of JAK1, which interferes with JAK/STAT (signal transducer
and activator of transcription)-dependent signaling. As JAK1 mediates signaling of
many pro-inflammatory cytokines, JAK1 inhibition prevents cytokine signaling and activity
in many inflammatory and immune-mediated processes and leads to a decrease in inflammation
and activation of certain immune cells. JAK1 plays a key role in the signaling and
activity of many cytokines and growth factors and is often dysregulated in a variety
of autoimmune and inflammatory diseases, as well as some malignancies.;
UNII : 2CQ8Y0B8XQ;
InChIKey : VLVWKOPMGYYNKV-UHFFFAOYSA-N;
CAS number : 1540859-07-1;
NCI Metathesaurus CUI : CL971566;
Origin ID : C166565;
UMLS CUI : C5238036;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
