NCIt definition : The hydrochloride salt form of pevonedistat, a small molecule inhibitor of Nedd8 activating
enzyme (NAE) with potential antineoplastic activity. Pevonedistat binds to and inhibits
NAE, which may result in the inhibition of tumor cell proliferation and survival.
NAE activates Nedd8 (Neural precursor cell expressed, developmentally down-regulated
8), an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that
is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). Functioning
in diverse regulatory activities, proteins conjugated to UBLs like Nedd8 typically
are not targeted for proteasomal degradation.;
Semantic type(s)