Lanadelumab - CISMeF

Preferred Label : Lanadelumab;

NCIt synonyms : Lanadelumab-flyo;

NCIt definition : A fully human immunoglobulin G1 (IgG1) monoclonal antibody against plasma kallikrein that can be used for the treatment of hereditary angioedema (HAE). Upon administration, lanadelumab targets and binds to plasma kallikrein, thereby inhibiting its proteolytic activity. This inhibits the cleavage of high-molecular-weight-kininogen (HMWK) into cleaved HMWK (cHMWK) and bradykinin. This in turn may prevent bradykinin-driven vasodilation, the resulting increase in vascular permeability, and the swelling and pain associated with HAE. This may also prevent or improve pulmonary edema not associated with HAE and improve the associated decrease in blood oxygen levels.;

UNII : 2372V1TKXK;

CAS number : 1426055-14-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1426055-14-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Takhzyro;

Molecule name : SHP643; DX-2930; TAK-743;

NCI Metathesaurus CUI : CL971536;

Details

Origin ID

C166535;

UMLS CUI

C4505508;

Automatic exact mappings (from CISMeF team)
- lanadelumab [ATC Code]
CISMeF manual mappings
- lanadelumab [MeSH concept]
Currated CISMeF NLP mapping
- Lanadelumab (substance) [SNOMED CT concept]
- lanadelumab [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Takhzyro [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lanadelumab (substance) [SNOMED CT concept]
- Product containing lanadelumab (medicinal product) [SNOMED CT concept]
- lanadelumab [ATC Code]
- lanadelumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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