Preferred Label : Alteminostat;
NCIt synonyms : HDAC Inhibitor CKD-581;
NCIt definition : A highly water-soluble, pan histone deacetylase (HDAC) inhibitor, with potential antineoplastic
activity. Upon administration, alteminostat targets and inhibits HDAC, resulting in
an accumulation of highly acetylated histones, the induction of chromatin remodeling,
and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene
transcription, and the selective transcription of tumor suppressor genes, which results
in the inhibition of tumor cell division and the induction of tumor cell apoptosis.
HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible
for the deacetylation of chromatin histone proteins.;
UNII : 1FM6TS1M0G;
InChIKey : YEQGPOVCXMZUBT-UHFFFAOYSA-N;
CAS number : 1246374-97-9;
Molecule name : CKD-581; CKD 581;
NCI Metathesaurus CUI : CL971500;
Origin ID : C166499;
UMLS CUI : C5238007;
Semantic type(s)
- concept_is_in_subset
