Telitacicept - CISMeF

Preferred Label : Telitacicept;

NCIt definition : A fusion protein composed of the extracellular domain of human tumor necrosis factor receptor superfamily member 13B (TNFRSF13B; transmembrane activator and calcium modulator and cyclophilin ligand interactor; TACI) fused to a human immunoglobulin (Ig) fragment crystallizable (Fc) domain, with potential immunomodulating activity. Upon administration, telitacicept targets both tumor necrosis factor ligand superfamily member 13B (TNFSF13B; BAFF; B lymphocyte stimulator; BLyS) and tumor necrosis factor ligand superfamily member 13 (TNFSF13; a proliferation-inducing ligand; APRIL) and inhibits their interaction with their cell membrane receptors, including TACI, tumor necrosis factor receptor superfamily member 17 (TNFRSF17; B-cell maturation antigen; BCMA) and tumor necrosis factor receptor superfamily member 13C (TNFRSF13C; BAFF receptor; BAFF-R). This inhibits B-cell proliferation and maturation, thereby inhibiting B-cell mediated autoimmune responses. APRIL and BAFF, and their interactions with their receptors TACI, BCMA and BAFF-R, play important roles in in B-cell proliferation and survival.;

UNII : 1FHM3D7Z49;

CAS number : 2136630-26-5;

Molecule name : RC-18; RC 18;

NCI Metathesaurus CUI : CL971497;

Details

Origin ID

C166498;

UMLS CUI

C5238006;

Currated CISMeF NLP mapping
- telitacicept [MeSH Supplementary Concept]
- telitacicept [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- telitacicept [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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