" /> Bempedoic Acid - CISMeF





Preferred Label : Bempedoic Acid;

NCIt definition : An orally bioavailable prodrug and inhibitor of adenosine triphosphate-citrate lyase (ACL), with anti-hyperlipidemic activity. Upon oral administration, bempedoic acid becomes activated to its thioester form with coenzyme A (CoA) by the enzyme very long-chain acyl-CoA synthetase 1 (ACSVL1; SLC27A2) in the liver. The activated form inhibits ACL, thereby preventing the liver's biosynthesis of cholesterol. This lowers low-density lipoprotein cholesterol (LDL-C) levels. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway.;

Alternative definition : ACC/AHA: Bempedoic acid decreases LDL cholesterol by inhibiting ATP-citrate lyase.;

UNII : 1EJ6Z6Q368;

InChIKey : HYHMLYSLQUKXKP-UHFFFAOYSA-N;

CAS number : 738606-46-7;

Drug name : Nexletol;

NCI Metathesaurus CUI : CL971493;

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04/05/2025


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