Cenicriviroc - CISMeF

Preferred Label : Cenicriviroc;

NCIt synonyms : CVC;

NCIt definition : An orally bioavailable, dual inhibitor of human C-C chemokine receptor types 2 (CCR2; CD192) and 5 (CCR5; CD195), with potential immunomodulating, anti-inflammatory and antiviral activities. Upon oral administration, cenicriviroc specifically binds to and prevents the activation of both CCR2 and CCR5. This inhibits the activation of CCR2/CCR5-mediated signal transduction pathways and may inhibit inflammatory processes. The G-protein coupled chemokine receptors CCR2 and CCR5 are expressed on the surface of monocytes and macrophages and stimulate their migration and infiltration; they play key roles in inflammation and autoimmune diseases. In addition, cenicriviroc inhibits human immunodeficiency virus (HIV)-1 entry via CCR5 coreceptor interaction.;

UNII : 15C116UA4Y;

InChIKey : PNDKCRDVVKJPKG-WHERJAGFSA-N;

CAS number : 497223-25-3;

Details

Origin ID

C166464;

UMLS CUI

C4279622;

Automatic exact mappings (from CISMeF team)
- catheterization, central venous [MeSH Descriptor]
- cenicriviroc [MeSH Supplementary Concept]
- cenicriviroc [MeSH concept]
- central venous catheter [Artificial nutrition thesaurus concept]
- central venous catheters [MeSH Descriptor]
- choroid plexus vascular circuit [UBERON concept]
- contractile vacuole complex [GO term]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- cenicriviroc [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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