" /> Cenicriviroc - CISMeF





Preferred Label : Cenicriviroc;

NCIt synonyms : CVC;

NCIt definition : An orally bioavailable, dual inhibitor of human C-C chemokine receptor types 2 (CCR2; CD192) and 5 (CCR5; CD195), with potential immunomodulating, anti-inflammatory and antiviral activities. Upon oral administration, cenicriviroc specifically binds to and prevents the activation of both CCR2 and CCR5. This inhibits the activation of CCR2/CCR5-mediated signal transduction pathways and may inhibit inflammatory processes. The G-protein coupled chemokine receptors CCR2 and CCR5 are expressed on the surface of monocytes and macrophages and stimulate their migration and infiltration; they play key roles in inflammation and autoimmune diseases. In addition, cenicriviroc inhibits human immunodeficiency virus (HIV)-1 entry via CCR5 coreceptor interaction.;

UNII : 15C116UA4Y;

InChIKey : PNDKCRDVVKJPKG-WHERJAGFSA-N;

CAS number : 497223-25-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 497223-25-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

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21/05/2024


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