Preferred Label : IL-12sc, IL-15sushi, IFNa and GM-CSF mRNA-based Immunotherapeutic Agent SAR441000;
NCIt definition : An immunotherapeutic agent utilizing mRNA to encode the cytokines interleukin-12sc
(IL-12sc), interleukin-15sushi (IL-15sushi), interferon alpha (IFNa) and granulocyte-macrophage
colony-stimulating factor (GM-CSF), with potential immunomodulating and antineoplastic
activities. Upon intratumoral administration of IL-12sc, IL-15sushi, IFNa and GM-CSF
mRNA-based immunotherapeutic agent SAR441000, mRNA is picked up by nearby cells, translated
and released into the local tumor microenvironment (TME). Secretion of these cytokines
activate the immune system by promoting the activation of natural killer cells (NKs)
and inducing cytotoxic T-lymphocyte (CTL) responses, which may result in an immune-mediated
destruction of tumor cells.;
Molecule name : SAR-441000; BNT-131; SAR 441000; BNT 131;
NCI Metathesaurus CUI : CL971627;
Origin ID : C166375;
UMLS CUI : C5237935;
Semantic type(s)
- concept_is_in_subset
