Preferred Label : Macrocycle-bridged STING Agonist E7766;
NCIt synonyms : Stimulator of Interferon Genes Agonist E7766; MBSA E7766; Sting Agonist E7766;
NCIt related terms : E-7766;
NCIt definition : An agonist of macrocycle-bridged stimulator of interferon genes (STING) protein, with
potential immunoactivating and antineoplastic activities. Upon intravenous administration,
macrocycle-bridged STING agonist (MBSA) E7766 targets and binds to STING and activates
the STING pathway, which promotes IKK-related kinase TANK-binding kinase 1 (TBK1)
signaling and activates nuclear factor-kappa B (NF-kB) and interferon regulatory factor
3 (IRF3) in immune cells in the tumor microenvironment (TME). This leads to the production
of pro-inflammatory cytokines, including interferons (IFNs). Specifically, expression
of IFN-beta (IFNb) enhances the cross-presentation of tumor-associated antigens (TAAs)
by CD8alpha-positive and CD103-positive dendritic cells (DCs) to cytotoxic T-lymphocytes
(CTLs). This results in a CTL-mediated immune response against tumor cells and causes
tumor cell lysis. Compared to conventional STING agonists, MBSA E7766 allows for conformational
rigidity of the unique macrocycle bridge which enhances its stability and STING affinity,
thereby increasing its efficacy.;
UNII : J81GDR86J9;
CAS number : 2242635-02-3;
Molecule name : E 7766; E-7766;
NCI Metathesaurus CUI : CL979196;
Origin ID : C166141;
UMLS CUI : C5237727;
Semantic type(s)
- concept_is_in_subset
- has_target
