Preferred Label : Anti-B7-H3 CAR T-cells;
NCIt synonyms : CARB7H3;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3,
CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with
potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H3
CAR T-cells target and bind to B7-H3-expressing tumor cells, thereby inducing selective
toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and
a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain
tumor cell types and on various immune cells. It is a negative regulator of T-cell
activation and its overexpression plays a key role in tumor cell invasion and metastasis.;
NCI Metathesaurus CUI : CL979044;
Origin ID : C165844;
UMLS CUI : C5237484;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
