Preferred Label : EGFR/EGFRvIII Inhibitor WSD0922-FU;
NCIt synonyms : EGFR Mutant Inhibitor WSD0922-FU; BBB Penetrable EGFR/EGFRvIII Inhibitor WSD0922-FU;
NCIt definition : A blood-brain-barrier (BBB) penetrable selective inhibitor of epidermal growth factor
receptor (EGFR) and various EGFR mutations, including but not limited to the EGFR
variant III (EGFRvIII) mutant form, with potential antineoplastic activity. Upon administration
of EGFR/EGFRvIII inhibitor WSD0922-FU, this agent is able to penetrate the BBB and
specifically targets, binds to and inhibits EGFR and specific EGFR mutations, which
prevents EGFR/EGFR mutant-mediated signaling and leads to cell death in EGFR/EGFR
mutant-expressing tumor cells. Compared to other EGFR inhibitors that are not able
to penetrate the BBB, WSD0922-FU may have therapeutic benefits in brain tumors, such
as glioblastoma (GBM) and metastatic CNS tumors. EGFR, a receptor tyrosine kinase
(RTK) that is mutated in many tumor cell types, plays a key role in tumor cell proliferation
and survival.;
Molecule name : WSD0922-FU; WSD 0922-FU;
NCI Metathesaurus CUI : CL979063;
Origin ID : C165778;
UMLS CUI : C5237453;
Semantic type(s)
- concept_is_in_subset
- has_target
